By unselecting the User product role for Confluence, you are removing the site-admins group from the default groups that manage roles for that product1. This means that ACME site admins will lose their Confluence admin permissions, such as managing Confluence settings, space permissions, etc2. They will still be able to see Confluence users, but not edit their roles or access.
References: Default groups and permissions, Confluence Admin Permission Levels Explained
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