In DKA, despite high blood glucose levels, thelack of insulinprevents glucose from entering cells. The body perceives this ascellular glucose deficiencyand responds by stimulatinggluconeogenesis(production of glucose from non-carbohydrate sources) andketogenesis, worsening hyperglycemia and acidosis.
“The insulin-deficient state in DKA leads to a cellular energy crisis, triggering gluconeogenesis due to a perceived intracellular glucose deficiency.”
(Referenced from CCRN Pediatric – Direct Care: Endocrine, Diabetic Ketoacidosis Pathophysiology)
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