High levels of PEEP(≥15 cm H₂O) can increaseintrathoracic pressure, leading todecreased venous returnand subsequentlydecreased cardiac output. This hemodynamic effect is the most immediate concern before longer-term issues like fibrosis arise.
“Elevated PEEP levels in ventilated children with RDS can compromise cardiac output by reducing preload. Monitor for hypotension and poor perfusion.”
(Referenced from CCRN Pediatric – Direct Care: Pulmonary, Mechanical Ventilation Complications)
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