Littoral cell angioma is a rare, benign vascular tumor of the spleen, arising from the littoral cells lining the splenic sinusoids. In contrast, lymphoma, metastasis, and angiosarcoma are malignant splenic neoplasms.
According to WHO Classification and Rumack’s Diagnostic Ultrasound:
“Littoral cell angioma is a rare benign vascular neoplasm of the spleen with characteristic imaging findings.”
[Reference:, Rumack CM, Wilson SR, Charboneau JW, Levine D. Diagnostic Ultrasound. 5th ed. Elsevier, 2017., WHO Classification of Tumours of the Digestive System, 5th ed., IARC, 2019., —]
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