To exclude files from malware scans, add them to the Exclusions list in the Malware Scan Configuration via the Deep Security Manager Web console. This is the official and recommended method.
From the official documentation:
“Files or folders added to the Exclusions list in the Malware Scan Configuration will not be scanned for malware.”
[References:, , Trend Micro Deep Security Anti-Malware Guide: Scan Exclusions, , Deep Security Help: Excluding Files from Scans]
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